Non-celiac gluten sensitivity

Since the recognition of dermatitis herpetiformis as a manifestation of gluten sensitivity it has become clear to many researchers that the bowel is not the only location in the body where gluten grains can wreak havoc. A modern visionary, Dr. Michael N. Marsh, first proposed a name change from celiac disease to gluten sensitivity (1). This might have facilitated an improved understanding of the many body systems and pathologies that gluten can induce among those who are susceptible. Dr. Marios Hadjivassiliou a similarly heroic medical figure continues to point out the many neurological manifestations among gluten-sensitive individuals (2). Many of these people suffer from celiac disease, but many more don't. Yet members of this larger group demonstrate anti-gliadin antibodies and strikingly similar types of neuropathy. Members of both groups can, if diagnosed early enough, halt or reverse their neurological ailments through strict adherence to a gluten-free diet. Non-celiac gluten sensitivity may be just as serious a condition as celiac disease.

1. Marsh MN. The small intestine: mechanisms of local immunity and gluten sensitivity.Clin Sci (Lond). 1981 Nov;61(5):497-503. Review.

2. Hadjivassiliou M, Williamson CA, Woodroofe N. The immunology of gluten sensitivity: beyond the gut. Trends Immunol. 2004 Nov;25(11):578-82

.