Okamoto M, Kuwahara A, Seo Mistunori, Kushiro T, Asami T, Hirai N, Kamiya Y, Koshiba T, Nambara E  (2006)  CYP707A1 and CYP707A2, which encode ABA 8'-hydroxylases, are indispensabe for a proper control of seed dormancy and germination in Arabidopsis.  Plant Physiol, Mar 16; [Epub ahead of print].  

Momoi K, Hofmann U, Schmid RD, Urlacher VB  (2006)  Reconstitution of beta-carotene hydroxylase activity of thermostable CYP175A1 monooxygenase.  Biochem Biophys Res Commun 339: 331-336.  PubMed

Wade RC, Motiejunas D, Schleinkofer K, Sudarko, Winn PJ, Banerjee A, Kaniakin A, Jung C  (2005)  Multiple molecular recognition mechanisms. Cytochrome P450 - A case study.  Biochim Biophys Acta Proteins Proteomics 1754 (1-2) Special Issue SI : 239-244.  

Leonard E, Yan YJ, Lim KH, Koffas MAG  (2005)  Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae.  Appl Environ Microbiol 71: 8241-8248.  PubMed

Kim HB, Kwon M, Ryu H, Fujioka S, Takatsuto S, Yoshida S, An CS, Lee I  (2006)  The regulation of DWARF4 expression is likely a critical mechanism in maintaining the homeostasis of bioactive brassinosteroids in Arabidopsis  Plant Physiol 140: 548-557.  PubMed

Ma HK, Zhang SB, Ji L, Zhu HB, Yang SL, Fang XJ, Yang RC  (2006)  Fine mapping and in silico isolation of the EUI1 gene controlling upper internode elongation in rice.  Plant Mol Biol 60 : 87-94.  PubMed

Fujita S, Ohnishi T, Watanabe B, Yokota T, Takatsuto S, Fujioka S, Yoshida S, Sakata K, Mizutani M  (2006)  Arabidopsis CYP90B1 catalyzes the early C-22 hydroxylation of C-27, C-28 and C-29 sterols.  Plant J 45: 765-774.  PubMed

Bach RD, Dmitrenko O  (2006)  The "somersault" mechanism for the P-450 hydroxylation of hydrocarbons. The intervention of transient inverted metastable hydroperoxides.  J Am Chem Soc 128: 1474-1488.  PubMed

Bode M, Haas M, Faymonville T, Thiede B, Schuphan I, Schmidt B  (2006)  Biotransformation of metamitron by human P450 expressed in transgenic tobacco cell cultures.  J Environ Sci Health Part B 41: 201-222.  PubMed

Lewis DFV, Ito Y, Goldfarb PS  (2005)  Cytochrome P450 structures and their substrate interactions.  Drug Develop Res 66: 19-24.  

Tian L, Dixon RA  (2006)  Engineering isoflavone metabolism with an artificial bifunctional enzyme.  Planta, Feb 16; [Epub ahead of print].  PubMed

Kim J, DellaPenna D  (2006)  Defining the primary route for lutein synthesis in plants: The role of Arabidopsis carotenoid {beta}-ring hydroxylase CYP97A3.  Proc Natl Acad Sci USA 103: 3474-3479.  PubMed

Bancos S, Szatmari A-M, Castle J, Kozma-Bognar L, Shibata K, Yokota T, Bishop GJ, Nagy F, Szekeres M  (2006)  Diurnal regulation of the brassinosteroid-biosynthetic CPD gene in Arabidopsis.  Plant Physiol, Mar 10; [Epub ahead of print].  PubMed

Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D  (2006)   Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.  Plant Cell, Mar 10; [Epub ahead of print].  PubMed

Hughes RK, Belfield EJ, Muthusamay M, Khan A, Rowe A, Harding SE, Fairhurst SA, Bornemann S, Ashton R, Thorneley RN, Casey R  (2006)  Characterization of Medicago trunculata hydroperoxide lyase (CYP74C3), a water-soluble detergent-free cytochrome P450 monomer whose biological activity is defined by monomer-micelle association.  Biochem J, Feb 2; [Epub ahead of print].  PubMed

Teoh KH, Polichuk DR, Reed DW, Nowak G, Covello PS  (2006)  Artemesia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.  FEBS Letters 580: 1411-1416.  PubMed

Rylott EL, Jackson RG, Edwards J, Womack GL, Seth-Smith HM, Rathbone DA, Strand SE, Bruce NC  (2006)  An explosive-degrading cytochrome P450 activity and its targeted application for the phytoremediation of RDX.  Nat Biotechnol 24: 216-219.  PubMed

Ojima K, Breitenbach J, Visser H, Setoguchi Y, Tabata K, Hoshino T, van den Berg J, Sandmann G  (2006)  Cloning of the astaxanthin synthase gene for Xanthophyllomyces dendrorhaus (Phaffia rhodozyma) and its assignment as a beta-carotene 3-hydroxylase/4-ketolase.  Mol Genet Genomics 275: 148-158. PubMed

Abdulrazzak N, Pollet B, Ehlting J, Larsen K, Asnaghi C, Ronseau S, Proux C, Erhardt M, Seltzer V, Renou J-P, Ullmann P, Pauly M, Lapierre C, Werck-Reichhart D  (2006)  A coumaroyl-ester-3-hydroxylase insertion mutant reveals the existence of nonredundant meta-hydroxylation pathways and essential roles for phenolic precursors in cell expansion and plant growth.  Plant Physiol 140: 30-48.  PubMed

Blobaum AL  (2006)  Mechanism-based inactivation and reversibility: is there a new trend in the inactivation of cytochrome P450 enzymes?  Drug Metab Dispos 34 :1-7.  PubMed

Cao JS, Yu XL, Ye WZ, Lu G, Xiang X  (2006)  Functional analysis of a novel male fertility CYP86MF gene in Chinese cabbage (Brassica campestris L ssp. chinenesis makino).  Plant Cell Rep 24: 715-723.  PubMed

Ipe BI, Niemeyer CM  (2006)  Nanohybrids composed of quantum dots and cytochrome P450 as photocatalysts.  Angew Chem Ed 45: 504-507.  PubMed

Zhu Y, Nomura T, Xu Y, Zhang Y, Peng Y, Mao B, Hanada A, Zhou H, Wang R, Li P, Zhu X, Mander LN, Kamiya Y, Yamaguchi S, He Z  (2006)  ELONGATED UPPERMOST INTERNODE encodes a cytochrome P450 monooxygenase that epoxidizes gibberellins in a novel deactivation reaction in rice.  Plant Cell 18: 442-456.  PubMed

Alcantara J, Bird DA, Franceschi VR, Facchini PJ  (2005)  Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment.  Plant Physiol 138: 173-183.  PubMed

Aoyama Y  (2005)  Recent progress in the CYP51 research focusing on its unique evolutionary and functional characteristics as a diversozyme P450.  Front Biosci 10: 1546-1557.  PubMed

Atkins WM  (2005)  Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.  Ann Rev Pharmacol Toxicol 45: 291-310.  PubMed

Axarli I, Prigipaki A, Labrou NE  (2005)  Engineering the substrate specificity of cytochrome P450 CYP102A2 by directed evolution: production of an efficient enzyme for bioconversion of fine chemicals.  Biomol Eng 22: 81-88.  PubMed

Benveniste I, Bronner R, Wang Y, Compagnon V, Michler P, Schreiber L, Salaun JP, Durst F, Pinot F  (2005)  CYP94A1, a plant cytochrome P450-catalyzing fatty acid omega-hydroxylase, is selectively induced by chemical stress in Vicia sativa seedlings.  Planta 221: 881-890.  PubMed

Booker J, Sieberer T, Wright W, Williamson L, Willett B, Stirnberg P, Turnbull C, Srinivasan M, Goddard P, Leyser O  (2005)  MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid-derived branch-inhibiting enzyme.  Dev Cell 8: 443-449.  PubMed  (CYP711A1)

Canals D, Irurre-Santilari J, Casas J  (2005)  The first cytochrome P450 in ferns. Evidence for its involvement in phytoecdysteroid biosynthesis in Polypodium vulgare.  FEBS J 272: 4817-4825.  PubMed

Celenza JL, Quiel JA, Smolen GA, Merrikh H, Silvestro AR, Normanly J, Bender J  (2005)  The Arabidopsis ATR1 Myb transcription factor controls indolic glucosinolate homeostasis.  Plant Physiol 137: 253-262.  PubMed

Coon MJ  (2005)  Cytochrome P450: Nature's most versatile biological catalyst.  Annu Rev Pharmacol Toxicol 45: 1-25.  PubMed

Cooper LD, Doss RP, Price R, Peterson K, Oliver JE  (2005)  Application of Bruchin B to pea pods results in the up-regulation of CYP93C18, a putative isoflavone synthase gene, and an increase in the level of pisatin, an isoflavone phytoalexin.  J Exp Bot 56: 1229-1237.  PubMed

Correia MA, Sadeghi S, Mundo-Paredes E  (2005)  Cytochrome P450 ubiquitination: branding for the proteolytic slaughter?  Ann Rev Pharmacol Toxicol 45: 439-464.  PubMed

Dejong JM, Liu Y, Bollon AP, Long RM, Jennewein S, Wiliams D, Croteau RB  (2005)  Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae.  Biotechnol Bioeng 93: 212-224.  PubMed

Duan H, Huang M-Y, Palacio K, Schuler MA  (2005)  Variations in CYP74B2 (hydroperoxide lyase) gene expression differentially affect hexenal signaling in the Columbia and Landsberg erecta ecotypes of Arabidopsis.  Plant Physiol 139: 1529-1544.  PubMed

Duan H, Schuler MA  (2005)  Differential expression and evolution of the Arabidopsis CYP86A subfamily.  Plant Physiol 137: 1067-1081.  PubMed

Dueckershoff K, Unger M, Frank A, Gillam EM, Guengerich FP, Warzecha H  (2005)  Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA.  FEBS Lett 579: 2480-2484.  PubMed

Ferhatoglu Y, Avdiushko S, Barrett M  (2005)  The basis for the safening of clomazone by phorate insecticide in cotton and inhibitors of cytochrome P450s.  Pest Biochem Physiol 81: 59-70.  

Grun S, Frey M, Gierl A  (2005)  Evolution of the indole alkaloid biosynthesis in the genus Hordeum: Distribution of gramine and DIBOA and isolation of the benzoxazinoid biosynthesis genes from Hordeum lechleri.  Phytochem 66: 1264-1272.  PubMed

Hazai E, Bikadi Z, Simonyi M, Kupfer D  (2005)  Association of cytochrome P450 enzymes is a determining factor in their catalytic activity.  J Comput Aided Mol Des 19: 271-285.  PubMed

Hirose S, Kawahigashi H, Ozawa K, Shiota N, Inui H, Ohkawa H, Ohkawa Y  (2005)  Transgenic rice containing human CYP2B6 detoxifies various classes of herbicides.  J Agric Food Chem 53: 3461-3467.  PubMed

Inoue K  (2005)  Cytochrome P450 enzymes in biosyntheses of some plant secondary metabolites.  Yakugaku Zasshi 125: 31-49.  PubMed

Jennewein S, Park H, DeJong JM, Long RM, Bollon AP, Croteau RB  (2005)  Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis.  Biotechnol Bioeng 89: 588-598.  PubMed

Kandel S, Morant M, Benveniste I, Blee E, Werck-Reichhart D, Pinot F  (2005)  Cloning, functional expression, and characterization of CYP709C1, the first sub-terminal hydroxylase of long chain fatty acid in plants. Induction by chemicals and methyl jasmonate.  J Biol Chem 280: 35881-35889.  PubMed

Ke N, Baudry J, Makris TM, Schuler MA, Sligar SG  (2005)  A retinoic acid binding cytochrome P450: CYP120A1 from Synechocystis sp. PCC 6803.  Arch Biochem Biophys 436: 110-120.  PubMed

Kim DG, Kim YJ, Lee SH, Lee I  (2005)  Effect of wounding and chemical treatments on expression of the gene encoding cinnamate-4-hydroxylase in Camptotheca acuminata leaves.  J Plant Biol 48: 298-303.  

Kim DH, Kim BG, Lee HJ, Lim YH, Hur HG, Ahn JH  (2005)  Enhancement of isoflavone synthase activity by co-expression of P450 reductase from rice.  Biotechnol Lett 27: 1291-1294.  PubMed

Kim GT, Fujioka S, Kozuka T, Tax FE, Takatsuto S, Yoshida S, Tsukaya H  (2005)  CYP90C1 and CYP90D1 are involved in different steps in the brassinosteroid biosynthesis pathway in Arabidopsis thaliana.  Plant J 41: 710-721.  PubMed

Kim HB, Schaller H, Goh CH, Kwon M, Choe S, An CS, Durst F, Feldman KA, Feyereisen R  (2005)  Arabidopsis CYP51 mutant shows postembryonic seedling lethality associated with lack of membrane integrity.  Plant Physiol 138: 2033-2047.  PubMed

Kim TW, Hwang JY, Kim YS, Joo SH, Chang SC, Lee JS, Takatsuto S, Kim SK  (2005)  Arabidopsis CYP85A2, a cytochrome P450, mediates the Baeyer-Villiger oxidation of castasterone to brassinolide in brassinosteroid biosynthesis.  Plant Cell 17: 2397-2412.  PubMed

Kirton SB, Murray CW, Verdonk ML, Taylor RD  (2005)  Prediction of binding modes for ligands in the cytochromes P450 and other heme-containing proteins.  Proteins 58: 836-844.  PubMed

Kitahata N, Saito S, Miyazawa Y, Umezawa T, Shimada Y, Min YK, Mizutani M, Hirai N, Shinozaki K, Yoshida S, Asami T  (2005)  Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors.  Bioorg Med Chem 13: 4491–4498.  PubMed

Kocuch S, Leifels T, Meyer D, Sbaragli L, Shaik S, Woggon WD  (2005)  New synthetic models of cytochrome P450: How different are they from the natural species?  Synlett (4): 675-684.  

Kristensen C, Morant M, Olsen CE, Ekstrøm CT, Galbraith DW, Møller BL, Bak S  (2005)  Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome.  Proc Natl Acad Sci USA 102: 1779-1784.  PubMed

Kuroda H, Oshima T, Kaneda H, Takashio M  (2005)  Identification and functional analyses of two cDNAs that encode fatty acid 9-/13-hydroperoxide lyase (CYP74-C) in rice.  Biosci Biotechnol Biochem 69: 1545-1554.  

Kwon M, Fujioka S, Jeon JH, Kim HB, Takatsuto S, Yoshida S, An CS, Choe S  (2005)  A double mutant for the CYP85A1 and CYP85A2 genes for Arabidopsis exhibits a brassinosteroid dwarf phenotype.  J Plant Biol 48: 237-244.  

Lewis DFV, Wiseman A  (2005)  A selective review of bacterial forms of cytochrome P450 enzymes - Review.  Enz Microbiol Technol 36: 377-384.  

Luo A, Qian Q, Yin Hengfu, Liu X, Yin C, Lan Y, Tang J, Tang Z, Cao S, Wang X, Xia K, Fu X, Lao D, Chu C  (2005)  EUI1, encoding a putative cytochrome P450 monooxygenase, regulates the internodes elongation by modulating GA responses in rice.  Plant Cell Physiol published 23 November 2005, 10.1093/pcp/pci233.  PubMed

Malonek S, Rojas MC, Hedden P, Gaskin P, Hopkins P, Tudzynski B  (2005)  Functional characterization of two cytochrome P450 monooxygenase genes, P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium proliferatum (Gibberella fujikuroi MP-D).  Appl Environ Microbiol 17: 1462-1472.  PubMed

Mestres J  (2005)  Structure conservation in cytochromes P450.  Proteins 58: 596-609.  PubMed

Mita G, Quarta A, Fasano P, De Paolis A, Di Sansebastiano GP, Perrotta C, Iannacone R, Belfield E, Hughes R, Tsesmetzis N, Casey R, Santino A  (2005)  Molecular cloning and characterization of an almond 9-hydroperoxide lyase, a new CYP74 targeted to lipid bodies.  J Exp Bot 56: 2321-2333.  PubMed

Nakamura M, Satoh T, Tanaka S-I, Mochizuki N, Yokota T, Nagatani A  (2005)  Activation of the cytochrome P450 gene, CYP72C1, reduces the levels of active brassinosteroids in vivo.  J Exp Bot 56: 833-840.  PubMed

Narusaka Y, Narusaka M, Seki M, Umezawa T, Ishida J, Nakajima M, Enju A, Shinozaki K  (2004)  Crosstalk in the responses to abiotic and biotic stresses in Arabidopsis: analysis of gene expression in cytochrome P450 gene superfamily by cDNA microarray.  Plant Mol Biol 55: 327-342.  PubMed

Nomura T, Kushiro T, Yokota T, Kamiya Y, Bishop GJ, Yamaguchi S  (2005)  The last reaction producting brassinolide is catalyzed by cytochrome P450s, CYP85A3 in tomato and CYP85A2 in Arabidopsis.  J Biol Chem 280: 17873-17879.  PubMed

O’Brien M, Chantha SC, Rahier A, Matton DP  (2005)  Lipid signaling in plants. Cloning and expression analysis of the obtusifolial 14{alpha}-demethylase for Solanum chacoenense Bitt., a pollination- and fertilization-induced gene with obtusifolial and lanosterol demethylase activity.  Plant Physiol 139: 734-749.  PubMed

Oldham ML, Brash AR, Newcomer ME  (2005)  The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide.  Proc Natl Acad Sci USA 102: 297-302.  PubMed  (coral allene oxide synthase is not a P450 enzyme)

Reddy MS, Chen F, Shadle G, Jackson L, Aljoe H, Dixon RA  (2005)  Targeted down-regulation of cytochrome P450 enzymes for forage quality improvement in alfalfa (Medicago sativa L.).  Proc Natl Acad Sci USA 102: 16573-16578.  PubMed

Ro D-K, Arimura G-I, Lau SYW, Piers E, Bohlmann J  (2005)  Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase.  Proc Natl Acad Sci USA 102: 8060-8065.  PubMed

Roche’s AmpliChip CYP450 Test receives FDA clearance.  WebLink

Siminszky B, Gavilano L, Bowen SW, Dewey RE  (2005)  Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase.  Proc Natl Acad Sci USA 102: 14919-14924.  PubMed

Takahashi N, Nakazawa M, Shibata K, Yokota T, Ishikawa A, Suzuki K, Kawashima M, Ichikawa T, Shimada H, Matsui M  (2005)  shk1-D, a dwarf Arabidopsis mutant caused by activation of the CYP72C1 gene, has altered brassinosteroid levels.  Plant J 42: 13-22.  PubMed  (CYP72C1)

Takahashi S, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J  (2005)  Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes.  J Biol Chem 280: 3686-3696.  PubMed

Tanabe S, Ashikari M, Fujioka S, Takatsuto S, Yoshida S, Yano M, Yoshimura A, Kitano H, Matsuoka M, Fujisawa Y, Kato H, Iwasaki Y  (2005)  A novel cytochrome P450 is implicated in brassinosteroid biosynthesis via the characterization of a rice dwarf mutant, dwarf11, with reduced seed length.  Plant Cell 17: 776-790.  PubMed  (CYP724B1)

Thimmapuram J, Duan H, Liu L, Schuler MA  (2005)  Bicistronic and fused monocistronic transcripts are derived from adjacent loci in the Arabidopsis genome.  RNA 11: 128-138.  PubMed

Thorsoe KS, Bak S, Olsen CE, Imberty A, Breton C, Moller BL  (2005)  Determination of catalytic key amino acids and UDP sugar donor specificity of the cyanohydrin glucosyltransferase UGT85B1 from Sorghum bicolor. Molecular modeling substantiated by site-specific mutagenesis and biochemical analyses.  Plant Physiol 139: 664-673.  PubMed

Turk EM, Fujioka S, Seto H, Shimada Y, Takatsuto S, Yoshida S, Wang H, Torres QI, Ward JM, Murthy G, Zhang J, Walker JC, Neff MM  (2005)  BAS1 and SOB7 act redundantly to modulate Arabidopsis photomorphogenesis via unique brassinosteroid inactivation mechanisms.  Plant J 42: 23-34.  PubMed  (CYP72C1, CYP734A1)

Van Beilen JB, Holtackers R, Luscher D, Bauer U, Witholt B, Duetz WA  (2005)  Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida.  Appl Environ Microbiol 17: 1737-1744.  PubMed

Vila-Aiub MM, Neve P, Powles SB  (2005)  Resistance cost of a cytochrome P450 herbicide metabolism but not an ACCase target site mutation in a multiple resistant Lolium rigidum population.  New Phytol 167: 787-796.  PubMed

Wen Z, Baudry J, Berenbaum MR, Schuler MA  (2005)  Ile115Leu mutation in the SRS1 region of the insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel.  Protein Eng Design Select 18: 191-199.  PubMed

Wen-Sheng X, Xiang-Jing W, Tian-Rui R, Su-Qin C  (2005)  Purification of recombinant wheat cytochrome P450 monooxygenase expressed in yeast and its properties.  Protein Expr Purif 45: 54-59.  PubMed

Yang DH, Chung BY, Kim JS, Kim JH, Yun PY, Lee YK, Lim YP, Lee MC  (2005)  cDNA cloning and sequence analysis of the rice cinnamate-4-hydroxylase gene, a cytochrome P450-dependent monooxygenase involved in the general phenylpropanoid pathway.  J Plant Biol 48: 311-318.