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PLACEBO: THE MIRACLE DRUG

By Dr. Andrew Saul

"The placebo should not be given on demand or for unduly prolonged periods of time." (Jonothan G. Solomon, M.D. [1982] Placebo revisited: An update on a very useful agent. The Consultant. December).
Don't you just love that statement? Exactly how many patients abuse their placebo prescriptions? And just how many people die from placebo overdose? Ever since I first watched comedian Steve Martin do a Saturday Night Live routine about being "high on a new drug called Pla-cee-bo," I've questioned the scientific method a lot more often. The great majority of all illnesses are self limiting. About ninety percent of all sick people will either get better anyway or die anyway, no matter what the doctor does. So why have doctors? For the ten percent who need intervention, common sense would tell us. Just how much bias enters into medical practice? In so-called double blind studies, where neither experimenter nor subject know who got the active medicine and who got the sugar pill, there can be little doubt. Yet only about twenty percent of all medical and surgical procedures have ever been double-blind, placebo tested. Let's see if we've got this straight: Only ten percent can be helped, and only twenty percent of what will be tried is known to help. I haltingly say that twenty percent of ten percent is..., ah, is... is a small number.
As a visiting student at the Canberra Hospital in Australia, I attended a physician's seminar on a brand new treatment for migraine headache. The seminar was paid for by the drug company that, surprise surprise, made the very drug being reported on. Research on this particular medicine showed that it worked better than placebo. About 55 to 65% of patients taking it had relief, whereas only about 45% taking the placebo had relief. Consider the wonder of the real difference: 45 of one hundred had relief from thinking that they might possibly be taking an effective medication, whereas only 20 out of a hundred more actually got relief from definitely ingesting the active chemical. When we do placebo controlled, double blind studies, the pony to bet on is the sugar pill: it will be infinitely safer, unbelievably cheaper, and darn near as effective as the drug du jour.
Why, then don't we just go whole hog and just use placebos? Well, we have. In a little-publicized (and downright embarrassing) chapter of 19th century medical history, there was a movement among some physicians who had good reason to believe that the cures of the day were worse than the diseases. The very term "quack" was in fact first applied to medical doctors who gave their drug of choice, mercury, for almost anything. They were called "quicks," actually, for using "quicksilver," mercury's nickname. Some doctors rebelled against what we today would consider to be bona fide medical barbarism, such as bleeding by the pint, uterus removals for female hysteria, lower rib removals in woman so they could fit into corsets better, arsenic treatments for syphilis, and so forth.
So along come some dissident doctors who choose to give no medicines at all, just placebos. Their cure rate was high, their death rate unusually low, their popularity with patients very strong, their names today very much unsung. Just try to find information about them at you local medical library or museum. If you come across anything on this subject, please email links, articles and especially references to: drsaul@doctoryourself.com

Reprinted with permission from the DOCTOR YOURSELF NEWSLETTER, (Vol 1, No 16) copyright c 2001 by Andrew W. Saul. Subscriptions are free at http://www.doctoryourself.com

About 90% of patients who visit doctors have conditions that will either improve on their own or that are out of reach of modern medicine's ability to solve." (New England Journal of Medicine, Feb 7, 1991) It makes one wonder how many people get better because of medical treatment and how many in spite of it!

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