Duncan Crow
Wholistic Consultant

Degenerative Disorder and Anti-Aging Protocol


This autoimmune and degenerative disorder protocol has worked in neurodegenerative and mitochondrial disorders for which there is no cure. A non-drug protocol, it addresses age-related degeneration and degenerative and autoimmune diseases, the hallmark of which is low ATP production, that is, impaired cell metabolism resulting in cell senescence and cell death, obvious degeneration and wasting, shriveled organs, and the eventual death of the subject.



Inducible and age-related cofactors for disease:
  1. Manufacture of the antioxidant glutathione drops with age, also depleted with free radical and toxin load, AKA oxidative stress, illness, inflammation, infection, etc.
  2. The immune system is impaired with age as the thymus gland shrinks, less recovery takes place and fewer white blood cells might be produced due to reduced growth hormone; immune response also drops with stress from any source such as nutritional deficiency, chronic infection, emotional stress, illness, electromagnetic pollution, free radicals/oxidative stress, drugs, leaky gut syndrome.
  3. A crucial anti-clotting enzyme plasmin drops with age, causing thick blood, reduced oxygen to the tissues, clots, inflammation, fibrosis in the internal organs; clotting also increases in illness, free radical damage/oxidative stress, and inflammation.
  4. Master growth hormones HGH and IGF-1 drop with age and also by carbohydrate loading that results in an insulin rise or othewise chronically high insulin levels.
The fact that we address all of these in a program would be of particular importance to elderly readers and to people whose levels have been induced to fall, resulting in disease.

Reduce Toxin Load:

Mitochondrial disorders, according to medical courses can be caused by toxin load when they are not inherited. The reason why they are often seen as age-related may be reduced to accumulation of enough toxin load and low enough oxygen delivery to cause symptoms. The causes of mitochondrial impairment may be many, but as you'll see all of these diseases are more likely just different manifestations of the same disorder. Anything that can impair mitochondrial production of ATP energy, for example unsaturated oils, as seen in this study, can result in degenerative disease or cancer. Toxin load unbalances biological function by attaching to and impairing or damaging the mitochondria and other cellular structures, which necessarily interferes with cellular function. Sometimes, as in cancer or fibromyalgia, a trigger mechanism may catalyse the event into becoming apparent where the body had previously been maintaining equilibrium AKA 'homeostasis' despite the toxin load.

Promote bile flow into the stool; bile is full of toxins that can be recirculated by the liver if bile flow is impaired. Liver and gallbladder flush (the olive oil, epsom salts and lemon juice one) every three weeks until there are no more hepatic stones .

Support the liver, the biggest user of the body's master detoxifier and antioxidant enzyme glutathione, as it's breaking down toxins, by giving it glutathione precursors in the form of cold-processed, undenatured whey (plus selenium). Glutathione is directly involved in mitochondrial ATP energy production and it is also the main protector of the mitochondria. It is also the main support for the immune response, which is of interest because several studies link chronic infection to accelerated degeneration. When glutathione levels are low, infection is stimulated, and when high, infection is reduced. Cold processed whey selection.

Feed the good bowel flora (probiotics) the inulin they require to outcompete pathogenic organisms in the gut. This will reduce toxin production in the gut that goes on 24 hours a day. As you'll see if you follow the research, eating probiotics neither provides the required actively fementing culture, nor does it provide the numbers needed to effect much change. Inulin references.

Reduce exposure to dietary toxins and free radicals including inflammation-causing food. Saturated oils cause much less free radical damage than unsaturated and especially, polyunsaturated. The oils analysis spreadsheet in the coconut oil references shows this difference, and well-referenced articles such as The Oiling Of America and The Cholesterol Myths, which are available online, addresses public misconceptions on dietary fats and cholesterol. Reducing carbohydrate loading will help facilitate normal metabolic function, and controlling/improving lymph and cell alkalinity should be a concern, following Nobel Prize work on oxygen carrying ability of alkaline tissues and cancer.

Further, one should know that all drugs cause a degree of cellular impairment and many even cause mitochondrial damage even on their own as in the case of the statin drug class of cholesterol medication. Obviously, removing toxins from the diet and environment would be an advantage.

Improve Nutritional Profile:

Cold processed whey supplies very bioavailable proteins that are much more easily absorbed than meat or eggs in addition to supplying glutathione precursors. It contains all of the essential amino acids and two of the glyconutients used in the healing process. Cold processed whey selection.

Regardless of whether there is a known bowel disturbance, bowel malabsorption is common due to gut acidity (pH) being incorrect. Inulin, a PREbiotic, supports correct bowel ecology and pH and results in better nutritient absorption. See the inulin references.

Macrominerals like magnesium and potassium are usually deficient, as are the b-vitamins and vitamin D, so should be supplemented in fairly generaous quantities, for example a gram or more each of magnesium citrate and potassium chloride (No-Salt for example), 5,000 IU vitamin D, B-100 complex, and an extra gram or so of niacin or no-flush niacinamide.

Reduce the Damage with Antioxidant and Anti-inflammatory Supplements:

These disorders are marked by low antioxidant pool, so dietary changes such as limiting intake of the oxidizing unsaturated oils except for that which is absolutely necessary for essential fatty acids intake, are important. Instead, use more saturated fats and coconut oil that are low oxidizers. Severely limit carbohydrate intake and favor fibrous and vegetables, and do an antioxidant program of at least vitamin A, C, E, and coenzyme Q-10, which itself is directly involved in mitochondrial ATP production. Fish liver oil and cod liver oil should be used as an antiinflammatory; the essential fatty acids are also used to rebuild cell walls.

Promote Healing:

A program of HGH increase supports regneration throughout the body, including the neural sheath, muscles and organs. Peer-reviewed research appears here.

The reason to use it, and an often overlooked part of many protocols particularly those for the elderly, is that healing and regeneration absolutely requires human growth hormone HGH levels to be adequate. Unfortunately, HGH production drops with age and at 60 years the body releases just half the HGH levels it does at 30. Thus the body's ability to repair is halved, later even quartered, with the obvious result of accumulating degeneration (damage) associated with aging and disease, as reported by FOX TV and ABC NEWS' 20/20 .

Youthful regeneration can be restored with prescription HGH shots; however the much less expensive patented supplement SomaLife gHP is preferred by many thousand doctors and their clients. This video on growth hormone therapy is also worth a look.

The aloe vera mentioned above in Body Balance also has legendary healing properties, as many nutritional substances do, but again, these rely on adequate HGH release.

Improve Immune Response:

Degenerative illnesses are often called autoimmune disorders due to an overactive or inflammatory immune response, sometimes combined with underactive response to infection, as seen in Lupus. The immune system can be immunomodulated, or increased if too low and decreased if too high. Transfer factor is unique in that it not only is an immunomodulator, it increases the numbers of natural killer (NK) cells that don't need training, it also educates naive immune cells about a present or potential danger in your body and gives them a plan for action. This speeds up the recognition phase of a health threat and improves the immune system's ability to mount a counter-attack, thus making the duration of an illness shorter or avoiding the illness entirely. 4Life Research, home of Transfer Factor .. More information on Transfer Factor

Improve Circulation:

Newer research backs up the nutritional approaches; this study Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease says in part:
In the present review, we survey the literature to identify mitochondrial nutrients that can:
  1. protect mitochondrial enzymes and/or stimulate enzyme activity by elevating levels of substrates and cofactors;
  2. induce phase-2 enzymes to enhance antioxidant defenses;
  3. scavenge free radicals and prevent oxidant production in mitochondria, and
  4. repair mitochondrial membrane.

Nutritional approaches, however, are only as good as the delivery mechanism, your micro-circulation, and Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease for example, (Acta Neuropathol (Berl). 2000 Oct) highlights the difficulty of servicing brain cells, and all the cells, by moving the nutrition, toxins, and oxygen that would normalise cellular function due to inflammation and damaged or blocked capilliaries. Cells with impaired function have impaired energy output; this is a precancerous condition that results in cell death as ATP production falls.

The key point here is that the body's only anti-clotting fibrinolytic enzyme Plasmin is reduced as one ages. Its effectiveness can also be reduced in response to chronic inflammation, disease, toxin load and depleted antioxidant pool.
Search PubMed


Fibrinolytic medications are effective but can be used only infrequently because they carry bleeding risks.

Some metabolic enzymes on the other hand are both fibrinolytic and anti-inflammatory, and because they work by a different mechanism they are virtually risk-free. Nattokinase for example is four times as potent as plasmin, and it improves natural plasmin release. Taken on an empty stomach, fibrinolytic enzymes reduce coagulation, dissolve clots, plaque, and fibrosis and can improve circulation, even, unlike the drugs, where blood flow is almost completely blocked. Obviously this improves nutrient and oxygen delivery and toxin removal; the result is improved cell metabolism and ATP generation, healing, growth, normal function etc. I've selected the enzymes blend BlockBuster All Clear as one of the best blends on the market. More information on enzymes.

Reduce inflammatory Oils:

Flaxseed oil provides the essential fatty acid alpha-linolenic acid (ALA), which is thought to be a 'good' omega-3 oil; it's a common but faulty assumption that ALA is physiologically equivalent to omega-3 essential fatty acids EPA and DHA, and there is no known need for alpha-linolenic acid (ALA) independent of its conversion to EPA/DHA. And in adults the conversion rate is tiny; the US Environmental Protection Agency has posted this powerpoint presentation (slide 5) that explains less than 1% conversion of ALA to EPA (some sources say somewhat higher), and <0.01% to DHA.

Though these details have traditionally escaped the followers of Joanna Budwig and Udo Erasmus, fatty acids expert Dr. Floyd Chilton fully explains them in his book Inflammation Nation. Chilton says (page 97),
"I wish I could tell you that the (ALA) in flaxseed oil could replace wild fish as a rich source of EPA and DHA but the scientific literature simply does not support this contention. ...We do the conversion but very slowly, and we also eat a lot of fatty acids such as LA that 'compete' for enzymes that convert ALA to EPA and DHA, further limiting its conversion."
 This competition is most pronounced in the common North American diet with its low EPA/DHA and higher omega-6 fatty acid intake due to corn, canola, soy, and safflower oil intake. Even olive oil is primarily pro-inflammatory.

Further, cell walls contain negligible ALA and are high EPA and DHA, which explains why for more than maintenance you may need vastly more EPA and DHA than an ALA supplement can provide, and why fish oil supplements are more popular for inflammation than flax oil. And, unlike ALA, EPA and DHA are essential to health and can reverse illnesses such as coronary heart disease, skin disorders and cancer. Wild salmon oil, wild fish oil, and cod liver oil provide lots of EPA and DHA. Wild salmon oil, even minimally refined oil, has almost no impurities. Inflammation can be further reduced by adding GLA or Borage oil if your EPA/DHA are good.

Essential fatty acids references show the anti-cancer properties of these oils.

Support ATP Production:

ATP energy generation is facilitated with glutathione, the master antioxidant, the precusors for which are plentiful in cold-processed whey. Unfortunately, glutathione levels are low in disease, a factor in the obvious accelerated aging that people undergo when they are sick for awhile.

Ozone therapy is a valuable bio-oxidative therapy that reduces blood clumping, improves capilliary flow, triggers beneficial antioxidant manufacture, oxidizes toxins, heavy metals and infections, and increases tissue oxygen. It has been used to treat more than 254 diseases, including all of the neurodegeneratives and cancer. By supporting aerobic processes it directly supports increased ATP energy production. It is beyond the scope of this protocol to detail ozone therapy approaches but more information is available by contacting the author or this manufacturer. www.plasmafire.com. See also this primer, The Story of Ozone.




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