Duncan Crow
Wholistic Consultant

Metabolic Enzymes Reduce Heart Attack and Stroke


The biggest cause of heart disease, peripheral arterial disease and stroke is the excess blood coagulation that results from production of the body's anti-clotting enzyme falling off as one ages. The biggest cause of organ failure, kidney failure being biggest killer of the elderly, is fibrosis, which is marked by excess scarring and fibrin deposits.

Medicine manages coagulopathy with blood thinners that carry a bleeding risk that, according to research, makes for a "poor prognosis" in the event of a haemorrhagic stroke. Medicine also corrects arterial blockages with sporadic cleaning, stents, heart bypass surgery, and limb amputations. Obviously medicine knows of no cure, no reversal of the disorder, but circulation is know to improve considerably with a non-medical technique that simply addresses the cause, low plasmin and high inflammation.

Fibrinolytic Enzyme References


More than 20 enzymes are involved in the clot-creating coagulation cascade, but just one –- plasmin -– dissolves fibrin, the clotting protein, and thus breaks up small clots and coagulating blood. Unfortunately plasmin decreases with age, and this allows fibrin levels to rise and present a serious risk of heart attack or stroke.

Thrombolytic, or clot-busting, drugs on one hand can be used in the early treatment of many heart attack patients, but even when properly administered the drugs kill three in every 1,000 patients by making them bleed to death. Even with caution they are not useful for maintenance.

Warfarin and Coumadin relatives on the othe hand work by interfering with coagulation processes. The therapeutic window is very small, meaning a lowish dose doesn't work, and highish dose produces increased bleeding. For that matter even at the correc dose there is increased bleeding from minor wounds, increased oxidative stress due to chronic hemoglobin leakage, and also that elevated stroke risk with its poor prognosis, which becomes statistical even if the patient has been on warfarin (or aspirin) for only 3 months.

The non-drug approach instead uses metabolic (systemic) enzymes that have the clot-busting property of fibrin digestion; these specific fibrinolytic enzymes dissolve the actual clot material, without interfering with the natural ongoing process of coagulation, so there is little or no bleeding risk and no interference with wound healing. Nattokinase (NK) is in the family of oral systemic (metabolic) enzymes; the best fibrinolytic enzyme discovered, it is four times as effective than the body's natural clotbusting enzyme plasmin at dissolving fibrin directly, and studies indicate it may also enhance the body's own production of plasmin. When used on an empty stomach NK and a few others are effective in a variety of conditions involving fibrotic conditions, such as in adhesions and scar tissue from surgery or injury. In fact in Japan in its raw form as Natto, a garnish, it's been used for millennia for these properties. NK is more potent and economically feasible than any current clot buster including urokinase, so here you have something that’s backed by research that shows it would work in stroke, angina, venous stasis, thrombosis emboli, atherosclerosis, fibromyalgia, fatigue, claudication, retinal pathology, hypertension, diabetes, deep vein thrombosis and arterial embolism”, says Garry Gordon, whom some call the Genius of Complementary Medicine.

I have selected (10/2005) a new blend BlockBuster All Clear as a superior and cost competitive formula. Nattokinase has been shown to lower systolic blood pressure by up to 11% and diastolic pressure by up to 9.7% in those who needed it. In fact it is a safe and viable preventive anti-clotting blood thinner that can substitute for warfarin (Coumadin) or daily aspirin for patients. Any health-conscious individual who wishes to use a natural therapy to prevent unnecessary blood clotting and reduce inflammation can use it. Though hemophiliacs and borderline hemophiliacs should be cautious, no incidents of the blood getting too thin have been reported with any enzyme including nattokinase. Though experts agree that NK is remarkably safe and virtually non-toxic for use by people who are not already using anticoagulant-type drugs, if patients already are using warfarin, heparin or other anticoagulants their dosage will be necessarily reduced by your doctor. If you use enzymes you can continue to use supplements that help keep platelets “slippery” or reduce inflammation, such as omega 3 oils, garlic, ginkgo biloba, or vitamin E.

Research is validating the clinically-seen effect that enzymes keep stents open longer and improve both clogged arterial and micro-circulation. Many diabetics have avoided limb amputation when clots and plaque were removed and full circulation was restored in as little as 48 hours by several enzymes including serrapeptase, also called serratia peptidase, which has been shown to induce intense clot busting, anti-inflammatory and anti-edemic activity. As inflammation increases fibrinogen levels and increased fibrinogen increases clotting risk, the powerful anti-inflammatory activity of serrapeptase nicely complements the excellent clot busting activity of nattokinase. See some serrapeptase research here.

Although the activity, the oral absorption and the outcomes of enzymes have been proven over the years, only more advanced doctors have adopted this no-brainer.

I have selected BlockBuster All Clear because it's powerful and inexpensive; it contains the most potent, standard nattokinase NSK-SD™ as well as serrapeptase and Seaprose S.
Metabolic enzymes for endometriosis, fibroids and adhesions


Metabolic enzymes are unsurpassed for safely dissolving fibrosis and adhesions. In fact, no other remedy has this ability. Fibromyalgia patients would be impressed to learn the therapy does not discriminate between fibrosis and arterial blockages, but the therapy should interest everyone of both sexes.



Fibrinolytic Enzyme References


This subject is of general interest because after about age 27 or so EVERYONE experiences a reduced output of anti-clotting enzymes, so tissues begin to lose their elasticity and organs begin to shrink, harden and reduce function as fibrosis begins to accumulate. Fibrosis is the leading cause of organ failure in aging, and enzyme therapy to reduce this occurrence represents a very powerful ounce of prevention that makes tissues, organs and arteries more resilient, less blocked and more functional again in a very short time.

A diagram of adhesions, online here, comes with the description, Adhesions are strands of scar tissue that form in response to abdominal surgery and extend beyond the specific site of incision. Scar tissue that mends the incision is normal, but the adhesions form additionally under some circumstances that are not fully understood.

How adhesions are formed may not be fully researched, but we know they occur particularly in older patients who do not have enough enzymes to dissolve the fibrin, and we also know that peer-reviewed journals have contained information on preventing and dissolving adhesions and scars for quite some time. The prevention of peritoneal adhesions by papain was published in Annals of Surgery in 1936, Use of papase in prevention of experimental peritoneal adhesions came up in 1969 in Surgery, Bromelain therapy for the prevention of episiotomy pain appeared in Obstetrics and Gynecology in 1967, and a study called Plant enzymes in oral surgery appeared in Oral Surgery in 1965. Papain and other digestive enzymes have been used to treat ulcers, dissolve membranes in diphtheria, and reduce swelling, fever and adhesions after surgery for about 50 years all told, and it's commonly accepted that protein-digesting enzymes reduce fibrosis with no side effects. These earlier attempts used enzymes that are not particularly good at it; the new develpment is the discovery and application of enzymes that do it better.

Dr. Chris Serafini says in an article titled Neprinol and Endometriosis , The (oral) enzymes in Neprinol work swiftly to break apart fibroids, improve circulation, stimulate the immune system, and reduce inflammation. Neprinol's two foremost ingredients (Serrapeptase and Nattokinase) help remove fibroids by dissolving the fibrous part of the fibroid tumor. Clinical studies have shown that Serrapeptase and Nattokinase work fast and effectively to dissolve fibrin safely with no adverse side effects. Neprinol is extremely effective at removing toxins from the bloodstream, and then helping to pass the emulsified fibrous tissue. Fibrin and inflammation remain consistent among patients that have fibroids, arthritis, heart disease, and several other diseases. That being said, and although nattokinase and several other enzymes can dissolve clots, arterial blockages, fibrosis, scars and adhesions, reduce blood pressure and prevent clotting, their effect and their cost varies. The widely used test that measures fibrolytic units (FU) gives a positive result for practically all of the protein-digesting enzymes including those that do not dissolve fibrin very well; this can be explained by the more accurate ELISA test, which reveals that only one nattokinase, NSK-SD™, matches the molecular structure of the original discovery, and it is the only nattokinase that is endorsed by Dr. Sumi, the discoverer, and Dr. Holsworth, the leading U.S. researcher, of nattokinase.

I have selected (10/2005) a new blend BlockBuster All Clear as a superior and cost competitive formula.
Fibrinolytic Enzyme References

The following independent reference material is for educational purposes on this topic and it is not intended be associated with any company's product. No association is made in the research and none is intended.
Amano Enzyme USA Product Information
Application
Products
Form
Opt. pH
Opt. Temp
Specification
Dietary Supplement
α-Galactosidase DS
(Aspergillus niger)
Powder
3.0
60°C
α-Galactosidase activity
10,000 GalU/g(pH 5.5)
Amylase DS
(Aspergillus oryzae)
Powder
5.0
55°C
α-Amylase activity
90,000 DU/g(pH 4.8)
Cellulase DS
(Aspergillus niger)
Powder
4.5
55°C
Cellulase activity
110,000 CU/g(pH 4.5)
Diastase DS
(Barley Malt)
Powder
5.0
55°C
S-Amylase activity
12,000 u/g(pH 5.0)
Lactase 14-DS
(Aspergillus oryzae)
Powder
4.5
55°C
β-Galactosidase activity
14,000 ALU/g(pH 4.5)
Lipase DS
(Rhizopus oryzae)
Powder
6.5
45°C
Lipase activity
12,000 LU/g(pH 6.5)
Lipase F-DS
(Rhizopus oryzae)
Powder
7.0
40°C
Lipase activity
60,000 LU/g(pH 6.5)
NSK-SD (Nattokinase)
(Bacillus subtilis natto)
Powder
7.0
37°C
Nottokinase activity
20,000 FU/g(pH )
Acid Protease DS
(Aspergillus niger)
Powder
3.0
55°C
Protease activity
90,000 HUT/g(pH 4.7)
Protease A-DS
(Aspergillus oryzae)
Powder
7.0
50°C
Protease activity
300,000 HUT/g(pH 4.7)
Protease DS
(Aspergillus melleus)
Powder
8.0
45°C
Protease activity
150,000 HUT/g(pH 4.7)
Phytase DS
(Aspergillus niger)
Powder
5.5
55°C
Phytase activity
3,000 u/g(pH 6.0)
Seaprose S
(Aspergillus melleus)
Powder
8.0
45°C
Proteolytic activity
1,900 u/mg


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