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BONE AUGMENTATION USING PRP

 Patients with not enough bone for the placement of implants, can now, have the option to regenerate their bone using state of the art technology, and be able to enjoy the advantages of having Dental Implants. 

We use natural and/or artificial bone graft materials and barriers to improve the results, along with different techniques.

New Tissue Regeneration Technologies

     Platelet alpha granules contain potent growth factors necessary to begin tissue repair and regeneration at the wound site. Concentrated autologous platelets present huge reservoirs of growth factors that have the potential to greatly accelerate the normal healing process, naturally. The use of concentrated growth factors is considered by many to be a "new frontier" of clinical therapy and creates a paradigm shift affecting all segments of the medical profession.

New Standards of Care

     Clinicians in specialties such as dental, plastic & reconstructive, ENT, otolaryngology, orthopaedic, neurology, cardiovascular, vascular, general, non-healing wounds, and pediatric surgery routinely use concentrated platelets due to their ability to deliver a cocktail of bioactive growth factors. Growth factors shown to enhance the body's natural healing process include:
 

  • Platelet Derived Growth Factors (PDGF) initiate connective tissue healing including bone regeneration and repair. PDGF also increases mitogenesis (healing cells), angiogenesis (endothelial mitosis into functioning capillaries), and macrophage activation (debridement of the wound site and second phase source of growth factors).
  • Transforming Growth Factor Beta (TGF-ß ) increases the chemotaxis and mitogenesis of osteoblast precursors and they also stimulate osteoblast deposition of the collagen matrix of wound healing and bone regeneration.
  • Epidermal Growth Factors (EGF) induce epithelial development and promote angiogenesis.
  • Vascular Endothelial Growth Factors (VEGF) have potent angiogenic, mitogenic, and vascular permeability-enhancing activities specific for endothelial cells.

Improving Patient Outcomes

 Clinicians have reported that the use of growth factors from platelet rich plasma can enhance:

  • Bone Growth and Maturation
  • Graft Stabilization
  • Wound Sealing
  • Wound Healing
  • Hemostasis

SmartPReP™

 Harvest's second technology platform consists of two devices designed to produce point-of-care, autologous hemobiologic products. Specifically, in the operating room, SmartPReP™ separates autologous whole blood into RBC's, platelet poor plasma (PPP) and a pure platelet concentrate (PC) with the full compliment of associated growth factors. Since the platelet concentration and growth factor levels are easily controlled by volume, the clinician can achieve a predetermined level of growth factors tailored to a specific clinical application.

AutoSeal™

 The second device, AutoSeal™, is designed to produce a concentrated pellet of fibrinogen from the patients own blood - in the operating room during the procedure. This autologous biologic product also contains significantly high levels of growth factors.

By offering a fibrinogen product with growth factors, clinicians can expect the additional benefit of improved tissue repair and regeneration. Also, the fibrinogen/thrombin matrix can be a valuable vehicle for carrying pharmacological agents as well as chemotoxic agents used in oncology applications. The strength of the matrix can be modified to allow a timed release of these agents.

Both the SmartPReP and AutoSeal have the advantage of preparing the required autologous hemobiologic product quickly and easily at point-of-care with as little as 45 mL of the patient's blood.  Among the other advantages of the device are:

  • Safety: end product manufactured from patient’s own blood at point-of-care eliminates the risk of human disease transmission.
  • Ease of use: a single 50cc syringe loads the processing disposable and one button operation is all the clinical team is required to do.
  • Optimizes the environment for post-operative healing: concentrated levels of patient’s own platelets with concentrated levels of growth factors, delivered exactly to the operative site, optimizes natural tissue growth and accelerates healing.
  • Product flexibility: platelet or fibrinogen concentrate can be manipulated easily by the clinical team to any desired concentration.
  • Simple logistics: no requirement to schedule specialized personnel, equipment, or prepared materials.
  • Low cost: per unit cost is significantly less than other fibrin glue or platelet gel products.
  • Speed of preparation: platelet concentrate for platelet gel (approximately 10 minutes) and fibrinogen for fibrin glue (approximately 20 minutes).