Chorionic Villus Sampling
Can be performed in 1st trimester from
10-12 wks GA
technically more difficult than amniocentesis
loss risk of 1.3% vs amniocentesis (0.5%)
Measure fetal heart rate before and after procedure
transcervical vs transabdominal approach is dictated by placental location, with sample of fetal trophoblasts obtained from fetus. Need to try to obtain ~10 chorionic fronds, by a 19 gauge needle, or biopsy forceps.
Risk of Rh sensitization is controversial, with some reports suggesting Rhogam following CVS increases fetal loss.
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technically more difficult than amniocentesis
loss risk of 1.3% vs amniocentesis (0.5%)
Measure fetal heart rate before and after procedure
transcervical vs transabdominal approach is dictated by placental location, with sample of fetal trophoblasts obtained from fetus. Need to try to obtain ~10 chorionic fronds, by a 19 gauge needle, or biopsy forceps.
Risk of Rh sensitization is controversial, with some reports suggesting Rhogam following CVS increases fetal loss.
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