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CYP76s


P450 Function Plant Species
CYP76B6 geraniol 10-hydroxylase periwinkle
CYP76C1 geraniol 10-hydroxylase Arabidopsis


CYP76B6:   geraniol 10-hydroxylase, biosynthesis of iridoid monoterpenoids and several classes of monoterpenoid alkaloids, periwinkle (Catharanthus roseus).
1)  Hallahan DL, West JM  (1995)  Cytochrome P-450 in plant/insect interactions: geraniol 10-hydroxylase and the biosynthesis of iridoid monoterpenoids.  Drug Metabol Drug Interact 12: 369-382.  PubMed
2)  Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J  (2001)  Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis.  FEBS Lett 508: 215-220.  PubMed
3)  Burlat V, Oudin A, Courtois M, Rideau M, St-Pierre B  (2004)  Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites.  Plant J 38: 131-141.  PubMed

CYP76C1:   geraniol/nerol 10-hydroxylase.
Ohta D, Mizutani M  (1998)  Plant geraniol/nerol 10-hydroxylase and DNA coding therefor.  US Patent No. 5753507


Comments? Questions?   email:  joan.krochko@nrc-cnrc.gc.ca   website:  P450s in Plants
Plant Biotechnology Institute, National Research Council, Saskatoon, Saskatchewan   CANADA   S7N0W9
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