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CYP74A's


P450 Function Plant Species
CYP74A1 : allene oxide synthase (AOS) flaxseed
CYP74A allene oxide synthase (AOS) Arabidopsis
CYP74A3 allene oxide synthase (AOS) barley
CYP74A allene oxide synthase (AOS) corn
CYP74A allene oxide synthase (AOS) tomato
CYP74A allene oxide synthase (AOS) rice


CYP74A1:   allene oxide synthase (AOS), flaxseed (Linum usitatissimum).
Song W-C, Funk CD, Brash AR  (1993)  Molecular cloning of an allene oxide synthase: A cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides.  Proc Natl Acad Sci USA 90: 8519-8523.  PubMed

CYP74A:   allene oxide synthase (AOS), jasmonic acid synthesis.
1)  Laudert D, Pfannschmidt U, Lottspeich F, Hollander-Czytko H, Weiler EW  (1996)  Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxidase synthesis (CYP74), the first enzyme of the octadecanoid pathway to jasmonates.  Plant Mol Biol 31: 323-335.  PubMed
2)  Park J-H, Halitschke R, Kim HB, Baldwin IT, Feldmann KA, Feyereisen R  (2002)  A knockout mutation in allene oxide synthase results in male sterility and defective wound signal transduction in Arabidopsis due to a block in jasmonic acid biosynthesis.  Plant J 31: 1-12.  PubMed

CYP74A3:   allene oxide synthase (AOS), barley (Hordeum vulgare).
Maucher H, Hause B, Feussner I, Ziegler J, Wasternack C  (2000)  Allene oxide synthases of barley (Hordeum vulgare cv. Salome): tissue specific regulation in seedling development.  Plant J 21: 199-213.  PubMed

CYP74A:   allene oxide synthase (AOS), corn (Zea mays).
Utsunomiya Y, Nakayama T, Oohira H, Hirota R, Mori T, Kawai F, Ueda T  (2000)  Purification and inactivation by substrate of an allene oxide synthase (CYP74) from corn (Zea mays L.) seeds.  Phytochemistry 53: 319-323.  PubMed

CYP74A:   allene oxide synthase (AOS), tomato (Lycopersicon esculentum).
1)  Howe GA, Lee GI, Itoh A, Li L, DeRocher AE  (2000)  Cytochrome P450-dependent metabolism of oxylipins in tomato. Cloning and expression of allene oxide synthase and fatty acid hydroperoxide lyase.  Plant Physiol 123:711-724.  PubMed
2)  Froehlich JE, Itoh A, Howe GA  (2001)  Tomato allene oxide synthase and fatty acid hydroperoxide lyase, two cytochrome p450s involved in oxylipin metabolism, are targeted to different membranes of chloroplast envelope.  Plant Physiol 125: 306-317.  PubMed

CYP74A:   allene oxide synthase (AOS), rice (Oryza sativa).
Agrawal GK, Rakwal R, Jwa NS, Han KS, Agrawal VP  (2002)  Molecular cloning and mRNA expression analysis of the first rice jasmonate biosynthetic pathway gene allene oxide synthase.  Plant Physiol Biochem 40: 771-782.  


Comments? Questions?   email:  joan.krochko@nrc-cnrc.gc.ca   website:  P450s in Plants
Plant Biotechnology Institute, National Research Council, Saskatoon, Saskatchewan   CANADA   S7N0W9
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